Trimethylamine oxide → 6,6,6-Trifluorohexanal

Reaction equation

Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([F:10])([F:9])[F:8].C[N+]([O-:15])(C)C>>[F:8][C:7]([F:10])([F:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=[O:15]

Participants

Reactant 2

HCID 1145Trimethylamine oxide

HCID 138454716-Bromo-1,1,1-trifluorohexane

Product 1

HCID 234681006,6,6-Trifluorohexanal

Procedure

Commercially available 6-bromo-1,1,1-trifluorohexane (Oakwood) and trimethylamine oxide were processed using the method described in example 137A to afford the title compound. MS (ESI+) m/z 154 (M+NH4—H2O)+.

Sources & evidence

ORD record: ord-98a8e60b8621483ba8418b38f910830e
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08835475B2

Reaction notes

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