N-(2-Amino-5-fluoro-phenyl)-5-bromo-2-chloro-benzamide → HCID 178505463, compound
Reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[NH:9][C:10](=O)[C:11]1[CH:16]=[C:15]([Br:17])[CH:14]=[CH:13][C:12]=1[Cl:18]>C(O)(=O)C>[Br:17][C:15]1[CH:14]=[CH:13][C:12]([Cl:18])=[C:11]([C:10]2[NH:1][C:2]3[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=3[N:9]=2)[CH:16]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Method 3,4—Step b A solution of N-(2-Amino-5-fluoro-phenyl)-5-bromo-2-chloro-benzamide (6.90 g, 20.12 mmol) in acetic acid (40 mL) was stirred at 80° C. overnight, solvent was then removed under reduced pressure and the crude purified by precipitation from diethylether to obtain 6.00 g of the title compound (92%).
Workup
- customsolvent was then removed under reduced pressure
- customthe crude purified by precipitation from diethylether
Sources & evidence
- ORD record
- ord-ed40964a733b4b15a0823cfd54635c3f
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08835648B2
Reaction notes
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