HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 77086Generated: October 26, 2026
Hydrochloric Acid → 1-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperidine-4-carboxylic acid hydrochloride
https://huagongshe.com/reaction/77086
Participants
| Role | Name | HCID | Charge |
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| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperidine-4-carboxylic acid ethyl ester | HCID 66977525 | — |
| Product | 1-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperidine-4-carboxylic acid hydrochloride | HCID 66977624 | — |
Reaction Steps
Method 11—Step b A mixture of 1-[3-(1-Methyl-1H-benzoimidazol-2-yl)-phenyl]-piperidine-4-carboxylic acid ethyl ester (3.10 g, 8.54 mmol) in 6N HCl (25.0 mL) was heated in microwave at 120° C. for 20 minutes. Then solvent was removed to obtain the title compound in quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08835648B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-3022dd85f3864658a6519426f83a199f |
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| Source note | uspto-grants-2014_09 |
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