1,4-Dioxane hydrochloride → (R)-2-Methoxy-1-phenylethanamine hydrochloride
Reaction equation
[ClH:1].O1CCOCC1.C(OC([NH:15][C@@H:16]([CH2:23][O:24][CH3:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C>>[ClH:1].[CH3:25][O:24][CH2:23][C@H:16]([NH2:15])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1Participants
3
Procedure
60 ml of 4N-HCl/dioxane solution was added to 4.02 g (16.0 mmols) of N-t-butoxycarbonyl-(R)-α-methoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure. 30 ml of ether were added to the residue, and this was further concentrated to obtain (R)-α-methoxymethylbenzylamine hydrochloride in quantitative yield.
Workup
- concentrationThe reaction mixture was concentrated under reduced pressure
- addition30 ml of ether were added to the residue
- concentrationthis was further concentrated
Sources & evidence
- ORD record
- ord-3d062dc2d8ab4e1391656e4f536498a8
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05723165
Reaction notes
Loading…