HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-azido-3-(5-bromothiophen-2-yl)acrylate → ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-azido-3-(5-bromothiophen-2-yl)acrylate | HCID 73166977 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate | HCID 13164349 | 82% |
Reaction Steps
Acrylate 60 (3.81 g, 12.6 mmol) in o-xylene was refluxed for 20 min. After removing the o-xylene, the crude product was purified by column chromatography (EtOAc/Hexane: 1/10) to give carboxylate 61 (2.83 g, 82%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841305B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-5f4536bbbabf40fe8757e28a2bdfa0eb |
| Source note | uspto-grants-2014_09 |