1,4-Dioxane hydrochloride → (1R)-2-ethoxy-1-phenylethan-1-amine hydrochloride
Reaction equation
[ClH:1].O1CCOCC1.C(OC([NH:15][C@@H:16]([CH2:23][O:24][CH2:25][CH3:26])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C>>[ClH:1].[CH2:25]([O:24][CH2:23][C@H:16]([NH2:15])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[CH3:26]Participants
3
Procedure
12.5 ml of 4N-HCl/dioxane solution were added to 0.66 g (2.5 mmols) of N-t-butoxycarbonyl-(R)-α-ethoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure, 30 ml of ether was added to the residue, and this was further concentrated to obtain (R)-α-ethoxymethylbenzylamine hydrochloride at a quantitative yield.
Workup
- concentrationThe reaction mixture was concentrated under reduced pressure, 30 ml of ether
- additionwas added to the residue
- concentrationthis was further concentrated
Sources & evidence
- ORD record
- ord-ae03dc6af35144969588f144b56bba80
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05723165
Reaction notes
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