N-benzyloxycarbonyl-beta-benzyl-L-aspartyl-D-isoleucine → alpha-L-aspartyl-D-isoleucine (R)-alpha-methoxymethylbenzylamide

Participants

Reaction Steps

The same process as in Example 15 was repeated, except that N-benzyloxycarbonyl-β-benzyl-L-aspartyl-D-isoleucine was used in place of N-benzyloxycarbonyl-β-benzyl-L-aspartyl-D-valine and that (R)-α-methoxymethylbenzylamine hydrochloride was used in place of (R)-α-ethoxymethylbenzylamine hydrochloride, and α-L-aspartyl-D-isoleucine (R)-α-methoxymethylbenzylamide was obtained as a solid product. The total yield was 22.1%.

Provenance & Evidence