(R)-(-)-2-Amino-1-propanol → 3-[5-(1,1-Difluoro-ethyl)-tetrazol-1-yl]-N-((S)-2-hydroxy-1-methyl-ethyl)-5-(5-methyl-pyridin-2-yl)-benzamide

HRID 77784

Reaction equation

HRID 77784 reaction equation
[F:1][C:2]([C:5]1[N:9]([C:10]2[CH:11]=[C:12]([CH:16]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][N:20]=3)[CH:18]=2)[C:13](O)=[O:14])[N:8]=[N:7][N:6]=1)([F:4])[CH3:3].[NH2:26][C@H:27]([CH3:30])[CH2:28][OH:29]>>[F:1][C:2]([C:5]1[N:9]([C:10]2[CH:11]=[C:12]([CH:16]=[C:17]([C:19]3[CH:24]=[CH:23][C:22]([CH3:25])=[CH:21][N:20]=3)[CH:18]=2)[C:13]([NH:26][C@@H:27]([CH3:30])[CH2:28][OH:29])=[O:14])[N:8]=[N:7][N:6]=1)([F:4])[CH3:3]

Participants

3

Reactant 2

HCID 80308(R)-(-)-2-Amino-1-propanolHCID 666643303-[5-(1,1-Difluoro-ethyl)-tetrazol-1-yl]-5-(5-methyl-pyridin-2-yl)-benzoic acid

Product 1

HCID 578513353-[5-(1,1-Difluoro-ethyl)-tetrazol-1-yl]-N-((S)-2-hydroxy-1-methyl-ethyl)-5-(5-methyl-pyridin-2-yl)-benzamide

Procedure

3-[5-(1,1-Difluoro-ethyl)-tetrazol-1-yl]-5-(5-methyl-pyridin-2-yl)-benzoic acid was reacted with (R)-2-amino-propan-1-ol using the procedure of step 4 of Example 5, to afford 3-[5-(1,1-Difluoro-ethyl)-tetrazol-1-yl]-N-((S)-2-hydroxy-1-methyl-ethyl)-5-(5-methyl-pyridin-2-yl)-benzamide, MS (M+H)=403.

Sources & evidence

ORD record
ord-24dabf7f7aeb47479c53a37f269640e4
Source dataset
uspto-grants-2014_09
Patent number
US08841336B2

Linked notes

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