3-Amino-N-methylbenzamide → HCID 23614591, compound

HRID 78375

Reaction equation

HRID 78375 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([OH:20])=O)=[CH:14][CH:13]=2)=[O:10])=[CH:4][C:3]=1[C:21]([F:24])([F:23])[F:22].[CH3:25][NH:26][C:27]([C:29]1[CH:30]=[C:31]([CH:33]=[CH:34][CH:35]=1)[NH2:32])=[O:28]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][C:12]2[CH:13]=[CH:14][C:15]([C:18](=[O:20])[NH:32][C:31]3[CH:33]=[CH:34][CH:35]=[C:29]([C:27](=[O:28])[NH:26][CH3:25])[CH:30]=3)=[CH:16][CH:17]=2)=[O:10])=[CH:4][C:3]=1[C:21]([F:23])([F:24])[F:22]

Participants

3

Reactant 2

HCID 6765263-Amino-N-methylbenzamideHCID 236145964-Chloro-3-(trifluoromethyl)phenyl-N'-(4-carboxyphenyl)urea

Product 1

HCID 23614591HCID 23614591, compound

Procedure

Entry 67: N-(4-Chloro-3-(trifluoromethyl)phenyl-N′-(4-ethoxycarbonylphenyl)urea was synthesized according to Method C1e. N-(4-Chloro-3-(trifluoromethyl)phenyl-N′-(4-ethoxycarbonylphenyl)urea was saponified according to Method D3 to give N-(4-chloro-3-(trifluoromethyl)phenyl-N′-(4-carboxyphenyl)urea. N-(4-Chloro-3-(trifluoromethyl)phenyl-N′-(4-carboxyphenyl)urea was coupled with 3-methylcarbamoylaniline according to Method D1b to give N-(4-chloro-3-(trifluoromethyl)phenyl-N′-(4-(3-methylcarbamoylphenyl)carbamoylphenyl)urea.

Sources & evidence

ORD record
ord-1008dcdb63024b7c9984d63fc86e0e51
Source dataset
uspto-grants-2014_09
Patent number
US08841330B2

Linked notes

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