2-Chlorocyclopentanone → 3,4,5,6-Tetrahydro-2H-cyclopenta(d)(1,3)thiazol-2-imine

HRID 78511

Reaction equation

HRID 78511 reaction equation
Cl[CH:2]1[CH2:6][CH2:5][CH2:4][C:3]1=O.[NH2:8][C:9]([NH2:11])=[S:10]>>[S:10]1[C:3]2[CH2:4][CH2:5][CH2:6][C:2]=2[N:8]=[C:9]1[NH2:11]

Participants

3

Reactant 2

HCID 127512-ChlorocyclopentanoneHCID 2723790Thiourea

Product 1

HCID 3322553,4,5,6-Tetrahydro-2H-cyclopenta(d)(1,3)thiazol-2-imine

Conditions

Temperature
70 °C

Procedure

A mixture of 2-chlorocyclopentanone (5.0 g, 40 mmol) and thiourea (3.0 g, 40 mmol) was heated at 70° C. for 3 hours. After cooling, the solid was triturated with ethanol and collected by filtration to afford the title compound. MS (ESI) m/z 141 (M+H)+.

Workup

  1. temperatureAfter cooling
  2. customthe solid was triturated with ethanol
  3. filtrationcollected by filtration

Sources & evidence

ORD record
ord-d641966f5d9548f29add4af141aa5c0f
Source dataset
uspto-grants-2014_09
Patent number
US08841334B2

Linked notes

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