2-Chloro-4-iodoaniline → 3-[(2-Chloro-4-iodophenyl)amino]isonicotinic acid
Reaction equation
[Cl:1][C:2]1[CH:8]=[C:7]([I:9])[CH:6]=[CH:5][C:3]=1[NH2:4].F[C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][N:19]=1)[C:14]([OH:16])=[O:15]>>[Cl:1][C:2]1[CH:8]=[C:7]([I:9])[CH:6]=[CH:5][C:3]=1[NH:4][C:17]1[CH:18]=[N:19][CH:11]=[CH:12][C:13]=1[C:14]([OH:16])=[O:15]Participants
3
Procedure
synthesized as intermediate 1 by reacting 15.7 mmol of 2-chloro-4-iodoaniline with 23.55 mmol 2-fluoroisonicotinic acid. LC/MS [(5.9 min; 376 (M+1)].
Workup
- customsynthesized as intermediate 1
- custom5.9 min
Sources & evidence
- ORD record
- ord-af0f6d7d565548c08aae7faa12423262
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08841459B2
Reaction notes
Loading…