1-Aminopiperidine → 3-[(2-fluoro-4-iodophenyl)amino]-N-piperidin-1-ylisonicotinamide

HRID 78787

Reaction equation

HRID 78787 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[N:19]1([NH2:25])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:25][N:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1)=[O:14]

Participants

3

Reactant 2

HCID 166581-AminopiperidineHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2×

Product 1

HCID 115030773-[(2-fluoro-4-iodophenyl)amino]-N-piperidin-1-ylisonicotinamide

Procedure

3-[(2-fluoro-4-iodophenyl)amino]-N-piperidin-1-ylisonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.30 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.47 mmol of piperidin-1-ylamine LC/MS [8.81 min; 441 (M+1)]

Sources & evidence

ORD record
ord-139364b514434d39bcd95b74abb50c97
Source dataset
uspto-grants-2014_09
Patent number
US08841459B2

Linked notes

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