4-Amino-1-butanol → 3-[(2-fluoro-4-iodophenyl)amino]-N-(4-hydroxybutyl)isonicotinamide

HRID 78805

Reaction equation

HRID 78805 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[OH:19][CH2:20][CH2:21][CH2:22][CH2:23][NH2:24]>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:24][CH2:23][CH2:22][CH2:21][CH2:20][OH:19])=[O:14]

Participants

3

Reactant 2

HCID 258684-Amino-1-butanolHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2×

Product 1

HCID 116116783-[(2-fluoro-4-iodophenyl)amino]-N-(4-hydroxybutyl)isonicotinamide

Procedure

3-[(2-fluoro-4-iodophenyl)amino]-N-(4-hydroxybutyl)isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.5 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.63 mmol of 4-hydroxy-butylamine. LC/MS [8.42 min; 430 (M+1)]

Workup

  1. customLC/MS [8.42 min; 430 (M+1)]

Sources & evidence

ORD record
ord-ca65e8ad557041fc99058c448bd9511a
Source dataset
uspto-grants-2014_09
Patent number
US08841459B2

Linked notes

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