3,6-Dichloropyridazine → N4-Cyclopentyl-5-(3,6-dichloro-4-pyridazinyl)-2,4-pyrimidinediamine

HRID 79196

Reaction equation

HRID 79196 reaction equation
[CH:1]1([NH:6][C:7]2[C:12](I)=[CH:11][N:10]=[C:9]([NH2:14])[N:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:15][C:16]1[N:17]=[N:18][C:19]([Cl:22])=[CH:20][CH:21]=1>>[CH:1]1([NH:6][C:7]2[C:12]([C:21]3[CH:20]=[C:19]([Cl:22])[N:18]=[N:17][C:16]=3[Cl:15])=[CH:11][N:10]=[C:9]([NH2:14])[N:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 673313,6-DichloropyridazineHCID 58299581N4-Cyclopentyl-5-iodo-2,4-pyrimidinediamine

Product 1

HCID 58299981N4-Cyclopentyl-5-(3,6-dichloro-4-pyridazinyl)-2,4-pyrimidinediamine

Procedure

Compound 323 was prepared from compound 243 and 3,6-dichloropyridazine using chemistry similar to that described in example 200. LCMS-ESI (POS), M/Z, M+1: Found 325.0.

Sources & evidence

ORD record
ord-4058dd0c6a494a81913f8c19afaa37cb
Source dataset
uspto-grants-2014_09
Patent number
US08841312B2

Linked notes

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