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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 7937Generated: October 25, 2026

1-Methylpiperazine → 2-isobutyl-4-(4-methyl-1-piperazinyl)-methyl-6-phenyl-2H-pyridazin-3-one

https://huagongshe.com/reaction/7937

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-MethylpiperazineHCID 53167—
Reactant2-isobutyl-4-methanesulfonyloxymethyl-6-phenyl-2H-pyridazin-3-oneHCID 21991562—
Reactant4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-oneHCID 67214099—
Product2-isobutyl-4-(4-methyl-1-piperazinyl)-methyl-6-phenyl-2H-pyridazin-3-oneHCID 2199142677.1%

Reaction Steps

Following the procedure of Example 1 (10), 2-isobutyl-4-methanesulfonyloxymethyl-6-phenyl-2H-pyridazin-3-one and 1-methylpiperazine were reacted to yield the title compound as a yellow oil (yield: 77.1%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07087606B2
Source datasetuspto-grants-2006_08
ORD IDord-40b31dad112f477da22ae7c8e274bb70
Source noteuspto-grants-2006_08