6-(3-fluoro-4-methylphenyl)-2-isobutyl-4-methane-sulfonyloxymethyl-2H-pyridazin-3-one → 2-isobutyl-4-methanesulfonyloxymethyl-6-(4-trifluoromet hylphenyl)-2H-pyridazin-3-one

HRID 7949

Reaction equation

HRID 7949 reaction equation
FC1C=C(C2C=C([CH2:20][O:21][S:22]([CH3:25])(=[O:24])=[O:23])C(=O)N(CC(C)C)N=2)C=CC=1C.O[C:27]1[C:28](=[O:48])[N:29]([CH2:44][CH:45]([CH3:47])[CH3:46])[N:30]=[C:31]([C:34]2[CH:39]=[CH:38][C:37]([C:40]([F:43])([F:42])[F:41])=[CH:36][CH:35]=2)[C:32]=1C>>[CH2:44]([N:29]1[C:28](=[O:48])[C:27]([CH2:20][O:21][S:22]([CH3:25])(=[O:24])=[O:23])=[CH:32][C:31]([C:34]2[CH:35]=[CH:36][C:37]([C:40]([F:42])([F:41])[F:43])=[CH:38][CH:39]=2)=[N:30]1)[CH:45]([CH3:46])[CH3:47]

Participants

3

Reactant 2

HCID 219915316-(3-fluoro-4-methylphenyl)-2-isobutyl-4-methane-sulfonyloxymethyl-2H-pyridazin-3-oneHCID 178418928HCID 178418928, compound

Product 1

HCID 219915502-isobutyl-4-methanesulfonyloxymethyl-6-(4-trifluoromet hylphenyl)-2H-pyridazin-3-oneYield 89.9%

Procedure

Following the procedure of Example 1 (9), 4-hydroxy-methyl-2-isobutyl-6-(4-trifluoromethylphenyl)-2H-pyridazin-3-one was reacted to yield the title compound as colorless fine-needles (yield: 89.9%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-b6ddb63eb53b46ee8d6f1449f5c6896e
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Linked notes

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