2-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid → 3-[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

HRID 79629

Reaction equation

HRID 79629 reaction equation
C(OC(N1[CH2:12][CH2:11][CH:10]([C:13](=[O:25])[NH:14][CH2:15][C:16]([C:18]2[CH:23]=[CH:22][C:21]([Br:24])=[CH:20][CH:19]=2)=[O:17])C1)=O)(C)(C)C.[C:26]([O:30][C:31]([N:33]1C(C(O)=O)C2C[CH:34]1[CH2:35][CH2:36]2)=[O:32])([CH3:29])([CH3:28])[CH3:27]>>[C:26]([O:30][C:31]([N:33]1[CH:10]([C:13](=[O:25])[NH:14][CH2:15][C:16]([C:18]2[CH:19]=[CH:20][C:21]([Br:24])=[CH:22][CH:23]=2)=[O:17])[CH:11]2[CH2:12][CH:34]1[CH2:35][CH2:36]2)=[O:32])([CH3:29])([CH3:28])[CH3:27]

Participants

3

Reactant 2

HCID 150563882-(tert-Butoxycarbonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acidHCID 596115123-[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 596106863-[2-(4-Bromo-phenyl)-2-oxo-ethylcarbamoyl]-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

Procedure

Following the procedure used to prepare compound 3-[2-(4-bromo-phenyl)-2-oxo-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester, except that 2-aza-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester was used instead of pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester.

Sources & evidence

ORD record
ord-891d0efa5c944a1baac72ca23182f73a
Source dataset
uspto-grants-2014_09
Patent number
US08841278B2

Linked notes

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