2-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-one → 2-(4-chlorocinnamyl)-6-(4-fluoro-3-methylphenyl)-4-hydroxymethyl-2H-pyridazin-3-one

HRID 7988

Reaction equation

HRID 7988 reaction equation
FC1C=C(F)C=CC=1C1C=C(CN2C(=O)C3=CC=CC=C3C2=O)C(=O)N(CC(C)C)N=1.[C:32]([C:35]1[C:36](=[O:59])[N:37]([CH2:49][CH:50]=[CH:51][C:52]2[CH:57]=[CH:56][C:55]([Cl:58])=[CH:54][CH:53]=2)[N:38]=[C:39]([C:41]2[CH:46]=[CH:45][C:44]([F:47])=[C:43]([CH3:48])[CH:42]=2)[CH:40]=1)(O)=[O:33]>>[Cl:58][C:55]1[CH:54]=[CH:53][C:52]([CH:51]=[CH:50][CH2:49][N:37]2[C:36](=[O:59])[C:35]([CH2:32][OH:33])=[CH:40][C:39]([C:41]3[CH:46]=[CH:45][C:44]([F:47])=[C:43]([CH3:48])[CH:42]=3)=[N:38]2)=[CH:57][CH:56]=1

Participants

3

Reactant 2

HCID 219915872-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-oneHCID 672131804-carboxy-2-(4-chlorocinnamyl)-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one

Product 1

HCID 672135772-(4-chlorocinnamyl)-6-(4-fluoro-3-methylphenyl)-4-hydroxymethyl-2H-pyridazin-3-one

Procedure

Following the procedure of Example 1 (8), 4-carboxy-2-(4-chlorocinnamyl)-6-(4-fluoro-3-methylphenyl)-2H-pyridazin-3-one was reacted to yield the title compound as slightly yellow needles (yield: 17.2%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-f3e9efc20bd94e9a93ba445badfcb9d1
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Linked notes

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