Sodium ion → (7RS,8aSR)-7-(4-Fluorophenoxy)methyl-2-(5-chloropyridin-2-yl)-1,2,3,4,6,7,8,8a-octahydro-pyrrolo[1,2-a]pyrazine

HRID 800140

Reaction equation

HRID 800140 reaction equation
[CH2:33]([OH:34])[CH2:35][CH:36]([CH3:37])[CH3:38].[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:8])[cH:6][cH:7]1.[F:15][c:16]1[cH:17][cH:18][c:19]([O:20][CH2:21][CH:22]2[CH2:23][CH:24]3[N:25]([CH2:26][CH2:27][NH:28][CH2:29]3)[CH2:30]2)[cH:31][cH:32]1.[Na+:10].[Na+:9].[O-:11][C:12](=[O:13])[O-:14]>>[c:2]1([N:28]2[CH2:27][CH2:26][N:25]3[CH:24]([CH2:23][CH:22]([CH2:21][O:20][c:19]4[cH:18][cH:17][c:16]([F:15])[cH:32][cH:31]4)[CH2:30]3)[CH2:29]2)[n:3][cH:4][c:5]([Cl:8])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 923Sodium ion2×HCID 19660Carbonate IonHCID 276852,5-DichloropyridineHCID 31260Isoamyl AlcoholHCID 20682345(7RS,8aSR)-7-(4-fluorophenoxy)methyl-1,2,3,4,6,7,8,8a-octahydro-pyrrolo[1,2-a]pyrazine

Product 1

HCID 9841887(7RS,8aSR)-7-(4-Fluorophenoxy)methyl-2-(5-chloropyridin-2-yl)-1,2,3,4,6,7,8,8a-octahydro-pyrrolo[1,2-a]pyrazine

Sources & evidence

ORD record
ord-0136bd401aae44e0a8ab1730d60cc5eb
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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