Chloroacetyl chloride → HCID 178457011, compound

HRID 80020

Reaction equation

[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH2:9][C:10](Cl)=[O:11].[CH:13]([N:16]=[C:17]=[S:18])([CH3:15])[CH3:14]>>[CH:1]1([N:7]2[C:10](=[O:11])[CH2:9][S:18]/[C:17]/2=[N:16]\[CH:13]([CH3:15])[CH3:14])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 3

HCID 6577Chloroacetyl chloride

HCID 7965Cyclohexylamine

HCID 75263Isopropyl Isothiocyanate

Product 1

HCID 178457011HCID 178457011, compound

Procedure

3-Cyclohexyl-2-[(Z)-isopropylimino]-thiazolidin-4-one is prepared starting from cyclohexylamine, chloroacetyl chloride and isopropylisothiocyanate following Method B. LC-MS: tR=0.83 min, [M+1]+=241, 1H NMR (CDCl3): δ 4.30 (tt, J=3.6, 12.0 Hz, 1H), 3.69 (s, 2H), 3.37 (hep, J=6.4 Hz, 1H), 2.40-2.25 (m, 2H), 1.84-1.75 (m, 2H), 1.64-1.50 (m, 2H), 1.40-1.20 (m, 4H), 1.14 (d, J=6.4 Hz, 6H).

Sources & evidence

ORD record: ord-a02decf412a843569f254b5a4c6b1db5
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: USRE045174E1

Linked notes

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