6-[2-(Cyclopropyl)pyrimidin-5-yl]-1,2,3,4-tetrahydroisoquinoline → 5-cyclopropyl-5-[[6-(2-cyclopropylpyrimidin-5-yl)-3,4-dihydro-1H-isoquinolin-2-yl]sulfonylmethyl]imidazolidine-2,4-dione

Reaction equation

[CH:1]1([c:4]2[n:5][cH:6][c:7](-[c:10]3[cH:11][c:12]4[c:17]([cH:18][cH:19]3)[CH2:16][NH:15][CH2:14][CH2:13]4)[cH:8][n:9]2)[CH2:2][CH2:3]1.[CH:20]1([C:23]2([CH2:30][S:31](=[O:32])(=[O:33])[Cl:34])[NH:24][C:25](=[O:29])[NH:26][C:27]2=[O:28])[CH2:21][CH2:22]1>>[CH:1]1([c:4]2[n:5][cH:6][c:7](-[c:10]3[cH:11][c:12]4[c:17]([cH:18][cH:19]3)[CH2:16][N:15]([S:31]([CH2:30][C:23]3([CH:20]5[CH2:21][CH2:22]5)[NH:24][C:25](=[O:29])[NH:26][C:27]3=[O:28])(=[O:32])=[O:33])[CH2:14][CH2:13]4)[cH:8][n:9]2)[CH2:2][CH2:3]1

Participants

Reactant 2

HCID 667348536-[2-(Cyclopropyl)pyrimidin-5-yl]-1,2,3,4-tetrahydroisoquinoline

HCID 72235573(4-Cyclopropyl-2,5-dioxoimidazolidin-4-yl)methanesulfonyl chloride

Product 1

HCID 1785185225-cyclopropyl-5-[[6-(2-cyclopropylpyrimidin-5-yl)-3,4-dihydro-1H-isoquinolin-2-yl]sulfonylmethyl]imidazolidine-2,4-dione

Sources & evidence

ORD record: ord-d1c0d89143c34430a86a6362b7e9c4d0
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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