Chloroform → 1-[(4-Hydroxyphenyl)methyl]-3,4,5,6,7,8-hexahydroisoquinoline-2(1H)-carbaldehyde

Reaction equation

[CH:25]([Cl:26])([Cl:27])[Cl:28].[Cl:19][C:20]([CH:21]=[O:22])([Cl:23])[Cl:24].[OH:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][CH:7]2[NH:8][CH2:9][CH2:10][C:11]3=[C:16]2[CH2:15][CH2:14][CH2:13][CH2:12]3)[cH:17][cH:18]1>>[OH:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][CH:7]2[N:8]([CH:21]=[O:22])[CH2:9][CH2:10][C:11]3=[C:16]2[CH2:15][CH2:14][CH2:13][CH2:12]3)[cH:17][cH:18]1

Participants

Reactant 3

HCID 6212Chloroform

HCID 6407Chloral

HCID 145561084-[(1,2,3,4,5,6,7,8-Octahydroisoquinolin-1-yl)methyl]phenol

Product 1

HCID 234600991-[(4-Hydroxyphenyl)methyl]-3,4,5,6,7,8-hexahydroisoquinoline-2(1H)-carbaldehyde

Sources & evidence

ORD record: ord-594c37d24ec34f7eaa1feb96785dc746
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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