Acetone → Ethyl 6-(5-chloro-2-((4-chloro-2-fluorobenzyl)oxy)benzyl)picolinate

HRID 802637

Reaction equation

HRID 802637 reaction equation
[C:21](=[O:22])([O-:23])[O-:24].[CH3:37][C:38](=[O:39])[CH3:40].[Cl:1][c:2]1[cH:3][cH:4][c:5]([OH:20])[c:6]([CH2:8][c:9]2[cH:10][cH:11][cH:12][c:13]([C:15](=[O:16])[O:17][CH2:18][CH3:19])[n:14]2)[cH:7]1.[Cl:27][c:28]1[cH:29][c:30]([F:36])[c:31]([CH2:32][Br:33])[cH:34][cH:35]1.[K+:25].[K+:26]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([O:20][CH2:32][c:31]2[c:30]([F:36])[cH:29][c:28]([Cl:27])[cH:35][cH:34]2)[c:6]([CH2:8][c:9]2[cH:10][cH:11][cH:12][c:13]([C:15](=[O:16])[O:17][CH2:18][CH3:19])[n:14]2)[cH:7]1

Participants

6

Reactant 5

HCID 180AcetoneHCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 27365514-Chloro-2-fluorobenzyl bromideHCID 59384254Ethyl 6-[(5-chloro-2-hydroxyphenyl)methyl]-2-pyridinecarboxylate

Product 1

HCID 59384237Ethyl 6-(5-chloro-2-((4-chloro-2-fluorobenzyl)oxy)benzyl)picolinate

Sources & evidence

ORD record
ord-3cc68883386246b48aebc641c10f6366
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

Loading…