2-Chlorobenzylamine → HCID 66988151, compound

Reaction equation

[Na].O[CH:3]=[C:4]1[CH2:8][CH2:7][O:6][C:5]1=[O:9].[Cl:10][C:11]1[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=1[CH2:13][NH2:14]>>[Cl:10][C:11]1[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=1[CH2:13][NH:14][CH:3]=[C:4]1[CH2:8][CH2:7][O:6][C:5]1=[O:9]

Participants

Reactant 2

HCID 666482-Chlorobenzylamine

HCID 66988753HCID 66988753, compound

Product 1

HCID 66988151HCID 66988151, compoundYield 75%

Procedure

Using 3-hydroxymethylenedihydrofuran-2-one sodium salt (10 mmol) and 2-chlorobenzylamine (11 mmol) and proceeding according to the abovementioned method A2, 3-(2-chlorobenzylamino)methylenedihydrofuran-2-one (1.54 g, efficiency: 75%) is produced in the form of a white powder.

Sources & evidence

ORD record: ord-7bafc3a5c1d741cc8d041f507b2fad31
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08846125B2

Reaction notes

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