2-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane → 1,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(6-methyl-1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol

Reaction equation

[CH3:21][c:22]1[cH:23][c:24]([NH2:37])[c:25]2[cH:26][n:27][n:28](-[c:31]3[cH:32][cH:33][cH:34][cH:35][cH:36]3)[c:29]2[cH:30]1.[F:1][c:2]1[cH:3][cH:4][c:5]([O:19][CH3:20])[c:6]([C:8]([CH2:9][C:10]2([C:13]([F:14])([F:15])[F:16])[O:11][CH2:12]2)([CH3:17])[CH3:18])[cH:7]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([O:19][CH3:20])[c:6]([C:8]([CH2:9][C:10]([OH:11])([CH2:12][NH:37][c:24]2[cH:23][c:22]([CH3:21])[cH:30][c:29]3[c:25]2[cH:26][n:27][n:28]3-[c:31]2[cH:32][cH:33][cH:34][cH:35][cH:36]2)[C:13]([F:14])([F:15])[F:16])([CH3:17])[CH3:18])[cH:7]1

Participants

Reactant 2

HCID 160992392-[2-(5-Fluoro-2-methoxyphenyl)-2-methylpropyl]-2-trifluoromethyloxirane

HCID 249380596-Methyl-1-phenyl-1H-indazol-4-amine

Product 1

HCID 119925191,1,1-Trifluoro-4-[5-fluoro-2-(methyloxy)phenyl]-4-methyl-2-{[(6-methyl-1-phenyl-1h-indazol-4-yl)amino]methyl}-2-pentanol

Sources & evidence

ORD record: ord-477a85685cab44be9f5d00ef4cb233ca
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…