1-(2-Hydroxyethyl)piperazine → 2-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-[4-(2-hydroxyethyl)-1-piperazinyl]methyl-2H-pyridazin-3-one

Participants

Role	Name	HCID	Charge
Reactant	1-(2-Hydroxyethyl)piperazine	HCID 7677	—
Reactant	4-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one	HCID 67214099	—
Reactant	2-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-methane sulfonyloxymethyl-2H-pyridazin-3-one	HCID 73858284	—
Product	2-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-[4-(2-hydroxyethyl)-1-piperazinyl]methyl-2H-pyridazin-3-one	HCID 67213400	65.1%

Reaction Steps

Following the procedure of Example 1 (10), 2-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-piperazineethanol were reacted to yield the title compound as slightly-yellow needles (yield: 65.1%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07087606B2
Source dataset	uspto-grants-2006_08
ORD ID	ord-05e673c9e6fa437aa9ab215ba6dafd87
Source note	uspto-grants-2006_08