4-Methoxycarbonylphenylboronic acid → Methyl 2-(1-cyclopropyl-6-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4'-piperidin]-1'-yl]carbonyl}-1H-indol-4-yl)benzoate

HRID 803853

Reaction equation

HRID 803853 reaction equation
[CH3:45][O:46][C:47](=[O:48])[c:49]1[c:50]([B:55]([OH:56])[OH:57])[cH:51][cH:52][cH:53][cH:54]1.[CH3:58][O:59][C:60]([c:61]1[cH:62][cH:63][c:64]([B:65]([OH:66])[OH:67])[cH:68][cH:69]1)=[O:70].[F:1][C:2]([F:3])([F:4])[S:5]([O:6][c:7]1[c:8]2[cH:9][cH:10][n:11]([CH:40]3[CH2:41][CH2:42]3)[c:12]2[cH:13][c:14]([C:16](=[O:17])[N:18]2[CH2:19][CH2:20][C:21]3([O:22][c:23]4[cH:24][cH:25][c:26](-[c:32]5[cH:33][n:34][n:35]([CH3:37])[cH:36]5)[cH:27][c:28]4[C:29](=[O:31])[CH2:30]3)[CH2:38][CH2:39]2)[cH:15]1)(=[O:43])=[O:44]>>[c:7]1(-[c:50]2[c:49]([C:47]([O:46][CH3:45])=[O:48])[cH:54][cH:53][cH:52][cH:51]2)[c:8]2[cH:9][cH:10][n:11]([CH:40]3[CH2:41][CH2:42]3)[c:12]2[cH:13][c:14]([C:16](=[O:17])[N:18]2[CH2:19][CH2:20][C:21]3([O:22][c:23]4[cH:24][cH:25][c:26](-[c:32]5[cH:33][n:34][n:35]([CH3:37])[cH:36]5)[cH:27][c:28]4[C:29](=[O:31])[CH2:30]3)[CH2:38][CH2:39]2)[cH:15]1

Participants

4

Reactant 3

HCID 27343694-Methoxycarbonylphenylboronic acidHCID 27734962-(Methoxycarbonyl)benzeneboronic acidHCID 582087121-cyclopropyl-6-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4'-piperidin]-1'-yl]carbonyl}-1H-indol-4-yl trifluoromethanesulfonate

Product 1

HCID 58208692Methyl 2-(1-cyclopropyl-6-{[6-(1-methyl-1H-pyrazol-4-yl)-4-oxospiro[chroman-2,4'-piperidin]-1'-yl]carbonyl}-1H-indol-4-yl)benzoate

Sources & evidence

ORD record
ord-4b6d04e3040641499d3e41599cc30631
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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