(2,3-Dihydro-1,4-benzodioxin-6-yl)boronic acid → 4-[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)pyridin-3-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane

HRID 80421

Reaction equation

HRID 80421 reaction equation
Br[C:2]1[CH:3]=[C:4]([N:8]2[CH2:16][CH:15]3[CH2:17][N:11]4[CH2:12][CH:13]([CH2:18][CH:9]2[CH2:10]4)[CH2:14]3)[CH:5]=[N:6][CH:7]=1.[O:19]1[C:24]2[CH:25]=[CH:26][C:27](B(O)O)=[CH:28][C:23]=2[O:22][CH2:21][CH2:20]1>>[O:19]1[C:24]2[CH:25]=[CH:26][C:27]([C:2]3[CH:3]=[C:4]([N:8]4[CH2:16][CH:15]5[CH2:17][N:11]6[CH2:12][CH:13]([CH2:18][CH:9]4[CH2:10]6)[CH2:14]5)[CH:5]=[N:6][CH:7]=3)=[CH:28][C:23]=2[O:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 2776178(2,3-Dihydro-1,4-benzodioxin-6-yl)boronic acidHCID 866492494-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

Product 1

HCID 498692954-[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)pyridin-3-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane

Procedure

The title compound was prepared from the product of Example 65A and (2,3-dihydro-1,4-benzodioxin-6-yl)boronic acid according to General Method B: LC-MS Method D (ESI+) m/z 364.0 (M+H)+, retention time 1.30 minutes.

Sources & evidence

ORD record
ord-d9fefd439a984581b8a5b474ef08c158
Source dataset
uspto-grants-2014_09
Patent number
US08846661B2

Linked notes

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