Dimethylamine → 2-cyclopropylmethyl-4-(3-dimethylaminopropyl)-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one

HRID 8043

Reaction equation

HRID 8043 reaction equation
[CH:1]1([CH2:4][N:5]2[C:10](=[O:11])[C:9]([CH2:12][CH2:13][CH2:14]OS(C)(=O)=O)=[CH:8][C:7]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([F:28])[CH:21]=3)=[N:6]2)[CH2:3][CH2:2]1.[CH3:29][NH:30][CH3:31]>>[CH:1]1([CH2:4][N:5]2[C:10](=[O:11])[C:9]([CH2:12][CH2:13][CH2:14][N:30]([CH3:31])[CH3:29])=[CH:8][C:7]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([F:28])[CH:21]=3)=[N:6]2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 219915592-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-(3-metha nesulfonyloxypropyl)-2H-pyridazin-3-one

Product 1

HCID 101553852-cyclopropylmethyl-4-(3-dimethylaminopropyl)-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-oneYield 64.7%

Procedure

Following the procedure of Example 7, 2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-(3-methanesulfonyloxypropyl)-2H-pyridazin-3-one and dimethylamine were reacted to yield the title compound as a yellow powder (yield: 64.7%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-3168b7d94c754219aa02a878634ae871
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Linked notes

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