(2-Ethoxyphenyl)boronic acid → 4-[5-(2-Ethoxyphenyl)pyridin-3-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane

HRID 80443Notes

Reaction equation

HRID 80443 reaction equation
Br[C:2]1[CH:3]=[C:4]([N:8]2[CH2:16][CH:15]3[CH2:17][N:11]4[CH2:12][CH:13]([CH2:18][CH:9]2[CH2:10]4)[CH2:14]3)[CH:5]=[N:6][CH:7]=1.[CH2:19]([O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1B(O)O)[CH3:20]>>[CH2:19]([O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[C:2]1[CH:3]=[C:4]([N:8]2[CH2:16][CH:15]3[CH2:17][N:11]4[CH2:12][CH:13]([CH2:18][CH:9]2[CH2:10]4)[CH2:14]3)[CH:5]=[N:6][CH:7]=1)[CH3:20]

Participants

3

Reactant 2

HCID 2734902(2-Ethoxyphenyl)boronic acidHCID 866492494-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

Product 1

HCID 498695714-[5-(2-Ethoxyphenyl)pyridin-3-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane

Procedure

The title compound was prepared from the product of Example 65A and 2-ethoxyphenylboronic acid according to General Method B: LC-MS Method D (ESI+) m/z 350.0 (M+H)+, retention time 1.40 minutes.

Sources & evidence

ORD record
ord-276a08624d1a4f52b37e6126b3af9355
Source dataset
uspto-grants-2014_09
Patent number
US08846661B2

Reaction notes

Loading…