2-Methoxybenzoyl chloride → N-[3-(3-{2-[(3-fluorophenyl)amino]-4-pyrimidinyl}pyrazolo[1,5-a]pyridin-2-yl)phenyl]-2-(methyloxy)benzamide

HRID 804463

Reaction equation

HRID 804463 reaction equation
[CH2:1]1[c:2]2[c:3]([cH:4][cH:5][c:6]([NH:7][c:8]3[n:9][c:10](-[c:11]4[c:12](-[c:13]5[cH:14][c:15]([NH:16][C:17](=[O:18])[c:19]6[cH:20][cH:21][cH:22][cH:23][cH:24]6)[cH:25][cH:26][cH:27]5)[n:28][n:29]5[cH:30][cH:31][cH:32][cH:33][c:34]45)[cH:35][cH:36][n:37]3)[cH:38]2)[CH2:39][CH2:40][NH:41]1.[CH3:72][O:73][c:74]1[c:75]([C:76](=[O:77])[Cl:78])[cH:79][cH:80][cH:81][cH:82]1.[NH2:42][c:43]1[cH:44][c:45](-[c:49]2[n:50][n:51]3[c:52]([cH:53][cH:54][cH:55][cH:56]3)[c:57]2-[c:58]2[n:59][c:60]([NH:64][c:65]3[cH:66][c:67]([F:71])[cH:68][cH:69][cH:70]3)[n:61][cH:62][cH:63]2)[cH:46][cH:47][cH:48]1>>[NH:42]([c:43]1[cH:44][c:45](-[c:49]2[n:50][n:51]3[c:52]([cH:53][cH:54][cH:55][cH:56]3)[c:57]2-[c:58]2[n:59][c:60]([NH:64][c:65]3[cH:66][c:67]([F:71])[cH:68][cH:69][cH:70]3)[n:61][cH:62][cH:63]2)[cH:46][cH:47][cH:48]1)[C:76]([c:75]1[c:74]([O:73][CH3:72])[cH:82][cH:81][cH:80][cH:79]1)=[O:77]

Participants

4

Reactant 3

HCID 889692-Methoxybenzoyl chlorideHCID 595114034-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(3-fluorophenyl)-2-pyrimidinamineHCID 59513880N-(3-{3-[2-(1,2,3,4-tetrahydro-7-isoquinolinylamino)-4-pyrimidinyl]-pyrazolo[1,5-a]pyridin-2-yl}phenyl)benzamide

Product 1

HCID 59513869N-[3-(3-{2-[(3-fluorophenyl)amino]-4-pyrimidinyl}pyrazolo[1,5-a]pyridin-2-yl)phenyl]-2-(methyloxy)benzamide

Sources & evidence

ORD record
ord-c7fc66455fd64339b2ec5844a24d5374
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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