HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-Fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(Diethylamino)-1-propanol | HCID 12159 | — |
| Reactant | Methanesulfonate | HCID 85257 | — |
| Reactant | 3-Fluoro-4-nitrophenol | HCID 520948 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene | HCID 22014733 | — |
Reaction Steps
A solution of 3-fluoro-4-nitrophenol (2 mmol) and methanesulfonate of 3-diethylamino-1-propanol (2.5 mmol) in DMF (4 mL) is added with K2CO3 (4 mmol) and heated following the general procedure III (Step A). The product, 2-fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene is obtained (470 mg) after purification using silica gel column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07087632B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-f375c00562a24af688c5e95063e27f6d |
| Source note | uspto-grants-2006_08 |