7-amino-4-(4-hydroxycyclohexyl)-2-methyl-2,3-dihydro-1H-isoindol-1-one → Diethyl (4-{[4-{[7-(cis-4-hydroxycyclohexyl)-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate

Reaction equation

[Cl:1][c:2]1[n:3][c:4]([NH:12][c:13]2[c:14]([O:28][CH3:29])[cH:15][c:16]([CH2:17][P:18]([O:19][CH2:20][CH3:21])([O:22][CH2:23][CH3:24])=[O:25])[cH:26][cH:27]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11].[NH2:30][c:31]1[cH:32][cH:33][c:34]([CH:42]2[CH2:43][CH2:44][CH:45]([OH:48])[CH2:46][CH2:47]2)[c:35]2[c:39]1[C:38](=[O:40])[N:37]([CH3:41])[CH2:36]2>>[c:2]1([NH:30][c:31]2[cH:32][cH:33][c:34]([CH:42]3[CH2:43][CH2:44][CH:45]([OH:48])[CH2:46][CH2:47]3)[c:35]3[c:39]2[C:38](=[O:40])[N:37]([CH3:41])[CH2:36]3)[n:3][c:4]([NH:12][c:13]2[c:14]([O:28][CH3:29])[cH:15][c:16]([CH2:17][P:18]([O:19][CH2:20][CH3:21])([O:22][CH2:23][CH3:24])=[O:25])[cH:26][cH:27]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11]