N,N-Diethyl-2-propanamine → Methyl N-{5-bromo-3-[(2-chloro-3,6-difluorobenzyl)amino]pyrazin-2-yl}-beta-alaninate

HRID 80563

Reaction equation

HRID 80563 reaction equation
Br[C:2]1[C:3]([NH:9][CH2:10][CH2:11][C:12]([O:14][CH3:15])=[O:13])=[N:4][CH:5]=[C:6]([Br:8])[N:7]=1.[Cl:16][C:17]1[C:24]([F:25])=[CH:23][CH:22]=[C:21]([F:26])[C:18]=1[CH2:19][NH2:20].C(N(C(C)C)CC)C>>[Br:8][C:6]1[N:7]=[C:2]([NH:20][CH2:19][C:18]2[C:21]([F:26])=[CH:22][CH:23]=[C:24]([F:25])[C:17]=2[Cl:16])[C:3]([NH:9][CH2:10][CH2:11][C:12]([O:14][CH3:15])=[O:13])=[N:4][CH:5]=1

Participants

4

Reactant 3

HCID 521913N,N-Diethyl-2-propanamineHCID 27735452-Chloro-3,6-difluorobenzylamineHCID 86659428methyl N-(3,5-dibromopyrazin-2-yl)-beta-alaninate

Product 1

HCID 86659427Methyl N-{5-bromo-3-[(2-chloro-3,6-difluorobenzyl)amino]pyrazin-2-yl}-beta-alaninate

Procedure

Methyl N-{5-bromo-3-[(2-chloro-3,6-difluorobenzyl)amino]pyrazin-2-yl}-β-alaninate was prepared from methyl N-(3,5-dibromopyrazin-2-yl)-β-alaninate and 2-chloro-3,6-difluorobenzylamine in the presence of N,N-diethylisopropylamine as described in Example 1.

Sources & evidence

ORD record
ord-47cfcfe66c8b487ab840a86e8593c189
Source dataset
uspto-grants-2014_09
Patent number
US08846664B2

Linked notes

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