HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 3,5-dimethyl-1-pyridin-2-yl-1H-pyrazole-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Hydrazinopyridine | HCID 78645 | — |
| Reactant | Ethyl 2-acetylacetoacetate | HCID 79063 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3,5-dimethyl-1-pyridin-2-yl-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 9856256 | — |
Reaction Steps
Similar to Example 1, 2-pyridylhydrazine (7.5 mmol, 0.8 g) and 2-acetyl-3-oxo-butyric acid ethyl ester (7.5 mmol, 1.3 g) were mixed in a solution of 50% pyridine in ethanol, then heated under reflux. The solvents were removed under vacuum and the residue purified over silica. The named product crystallized upon standing (m.p. 49° C.–50° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07087634B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-d66dcc09bc84436bab5835d34320f478 |
| Source note | uspto-grants-2006_08 |