4-(1-Pyrrolidinyl)piperidine → 2-Phenyl-3-pyrid-4-yl-6-(4-pyrrolidin-1-ylpiperid-1-yl)imidazo[1,2-b]pyridazine

Participants

Role	Name	HCID	Charge
Reactant	4-(1-Pyrrolidinyl)piperidine	HCID 78703	—
Reactant	6-Chloro-2-phenyl-3-pyrid-4-ylimidazo[1,2-b]pyridazine	HCID 59406954	—
Solvent	Ethanol	HCID 702	—
Product	2-Phenyl-3-pyrid-4-yl-6-(4-pyrrolidin-1-ylpiperid-1-yl)imidazo[1,2-b]pyridazine	HCID 59406955	—

Reaction Conditions

Temperature	155 °C

Reaction Steps

A mixture of 4.03 g (13.1 mmol) of 6-chloro-2-phenyl-3-pyrid-4-ylimidazo[1,2-b]pyridazine and 4.4 g (29 mmol) of 4-pyrrolidin-1-ylpiperidine in 50 mL of ethanol is heated at 155° C. for 4 hours. After cooling, the solvent is evaporated off under reduced pressure and the residue is chromatographed on silica gel, eluting with a mixture of dichloromethane and methanol (93:7).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846676B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-c2eb2d7b1f2042a3af4bc5b0db2ec5b6
Source note	uspto-grants-2014_09