3-(Ethoxycarbonyl)-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → 3'-Chloro-4-fluoro-4'-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-propyl]-biphenyl-3-carboxylic acid ethyl ester

HRID 808618

Reaction equation

HRID 808618 reaction equation
[Br:1][c:2]1[cH:3][c:4]([Cl:24])[c:5]([CH:8]([C:9]([C:10]([F:11])([F:12])[F:13])([OH:14])[c:15]2[cH:16][cH:17][c:18](=[O:22])[n:19]([CH3:21])[cH:20]2)[CH3:23])[cH:6][cH:7]1.[F:25][c:26]1[c:27]([C:35](=[O:36])[O:37][CH2:38][CH3:39])[cH:28][c:29]([B:32]([OH:33])[OH:34])[cH:30][cH:31]1>>[c:2]1(-[c:29]2[cH:28][c:27]([C:35](=[O:36])[O:37][CH2:38][CH3:39])[c:26]([F:25])[cH:31][cH:30]2)[cH:3][c:4]([Cl:24])[c:5]([CH:8]([C:9]([C:10]([F:11])([F:12])[F:13])([OH:14])[c:15]2[cH:16][cH:17][c:18](=[O:22])[n:19]([CH3:21])[cH:20]2)[CH3:23])[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 249017713-(Ethoxycarbonyl)-4-fluorophenylboronic Acid (contains varying amounts of Anhydride)HCID 574213205-[2-(4-bromo-2-chloro-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyridin-2-one

Product 1

HCID 666991203'-Chloro-4-fluoro-4'-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-propyl]-biphenyl-3-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-38f88c760a3943e18c0da6999e168b79
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Linked notes

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