3-Bromopropionitrile → 3-{4-[5-(4-Trifluoromethylphenyl)pyridin-2-yl]piperazin-1-yl}propionitrile

HRID 80907

Reaction equation

[F:1][C:2]([F:22])([F:21])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[N:13][CH:14]=2)=[CH:5][CH:4]=1.Br[CH2:24][CH2:25][C:26]#[N:27]>>[F:22][C:2]([F:1])([F:21])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH2:20][CH2:19][N:18]([CH2:24][CH2:25][C:26]#[N:27])[CH2:17][CH2:16]3)=[N:13][CH:14]=2)=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 170203-Bromopropionitrile

HCID 671450024-(5-(4-Trifluoromethylphenyl)pyridin-2-yl)piperazine

Product 1

HCID 159513893-{4-[5-(4-Trifluoromethylphenyl)pyridin-2-yl]piperazin-1-yl}propionitrile

Procedure

The title compound was prepared by a similar procedure to that described in Example 55, starting from 4-(5-(4-trifluoromethylphenyl)pyridin-2-yl)piperazine and 3-bromopropionitrile.

Sources & evidence

ORD record: ord-5d1a49e8409e448394314d8374735c27
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08846677B2

Linked notes

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