HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 3-(4-Cyclopropyl-piperazin-1-yl)-6-(3-nitro-phenyl)-pyridazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 1-Cyclopropylpiperazine | HCID 4742004 | — |
| Reactant | 3-Chloro-6-(3-nitrophenyl)pyridazine | HCID 12257504 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 3-(4-Cyclopropyl-piperazin-1-yl)-6-(3-nitro-phenyl)-pyridazine | HCID 58006601 | 5.2% |
Reaction Conditions
| Temperature | 80 °C |
|---|
Reaction Steps
To a solution of 3-chloro-6-(3-nitro-phenyl)-pyridazine (10.0 g, 424 mmol) in n-BuOH (150 mL) was added 1-cyclopropyl-piperazine (8.55 g, 678 mmol) and NH4Cl (2.27 g, 424 mmol) and the mixture was stirred for 48 h at 80° C. The solvent was removed under reduced pressure, and the residue was diluted with water. After alkalization with ammonia, the mixture was extracted with ethyl acetate. The extract was dried (Na2SO4) and concentrated to give 7.2 g of crude 3-(4-cyclopropyl-piperazin-1-yl)-6-(3-nitro-phenyl)-pyridazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846677B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-3666725acd2842338bbe8900b1198449 |
| Source note | uspto-grants-2014_09 |