HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 80987Generated: October 26, 2026
Methanol → tert-butyl 2-(N-(4-chlorobenzyl)piperazine-1-carboxamido)ethylcarbamate
https://huagongshe.com/reaction/80987
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Benzyl 4-({2-[(tert-butoxycarbonyl)amino]ethyl}[(4-chlorophenyl)methyl]carbamoyl)piperazine-1-carboxylate | HCID 53416583 | — |
| Reactant | KOH MeOH Water | HCID 86591755 | — |
| Solvent | Water | HCID 962 | — |
| Product | tert-butyl 2-(N-(4-chlorobenzyl)piperazine-1-carboxamido)ethylcarbamate | HCID 67135341 | 89% |
Reaction Steps
A mixture of benzyl 4-((2-(tert-butoxycarbonylamino)ethyl)(4-chlorobenzyl)carbamoyl)piperazine-1-carboxylate (200 mg, 0.38 mmol) in a KOH/MeOH/H2O (10 mL; prepared as a stock solution using 10 g KOH, 50 mL MeOH and 25 mL H2O) solution of was stirred for 2 hours at 80° C. The reaction was extracted with EtOAc, dried over NaSO4 and concentrated under reduced pressure to yield tert-butyl 2-(N-(4-chlorobenzyl)piperazine-1-carboxamido)ethylcarbamate (132 mg, 89%). MS (ESI) m/e (M+H+) 397.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08846683B2 |
|---|
| Source dataset | uspto-grants-2014_09 |
|---|
| ORD ID | ord-12cf4848e62f42c6bb7abe563c366f7f |
|---|
| Source note | uspto-grants-2014_09 |
|---|
