Acetone → N-((1RS,2SR)-2-Isopropylamino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide

Reaction equation

[CH3:27][C:28]([CH3:29])=[O:30].[NH2:1][CH:2]1[CH:3]([NH:8][C:9]([c:10]2[c:11]([O:24][CH3:25])[cH:12][c:13]([C:20]([F:21])([F:22])[F:23])[cH:14][c:15]2[C:16]([F:17])([F:18])[F:19])=[O:26])[CH2:4][CH2:5][CH2:6][CH2:7]1>>[NH:1]([CH:2]1[CH:3]([NH:8][C:9]([c:10]2[c:11]([O:24][CH3:25])[cH:12][c:13]([C:20]([F:21])([F:22])[F:23])[cH:14][c:15]2[C:16]([F:17])([F:18])[F:19])=[O:26])[CH2:4][CH2:5][CH2:6][CH2:7]1)[CH:28]([CH3:27])[CH3:29]

Participants

Reactant 2

HCID 180Acetone

HCID 76682998N-(2-aminocyclohexyl)-2-methoxy-4,6-bis(trifluoromethyl)benzamide

Product 1

HCID 76682969N-((1RS,2SR)-2-Isopropylamino-cyclohexyl)-2-methoxy-4,6-bis-trifluoromethyl-benzamide

Sources & evidence

ORD record: ord-caca2e97b756473ebcd180cf6cf891fd
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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