4-Benzyl-3-oxo-3,4-dihydropyrazine-2-carboxylic acid → 4-benzyl-N-(3-fluoro-4-(2-(4-(morpholine-4-carbonyl)phenyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-oxo-3,4-dihydropyrazine-2-carboxamide
Reaction equation
[CH2:33]([c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1)[n:40]1[c:41](=[O:49])[c:42]([C:46](=[O:47])[OH:48])[n:43][cH:44][cH:45]1.[NH2:1][c:2]1[cH:3][c:4]([F:32])[c:5]([O:6][c:7]2[c:8]3[c:9]([n:10][cH:11][cH:12]2)[cH:13][c:14](-[c:16]2[cH:17][cH:18][c:19]([C:22](=[O:23])[N:24]4[CH2:25][CH2:26][O:27][CH2:28][CH2:29]4)[cH:20][cH:21]2)[s:15]3)[cH:30][cH:31]1>>[NH:1]([c:2]1[cH:3][c:4]([F:32])[c:5]([O:6][c:7]2[c:8]3[c:9]([n:10][cH:11][cH:12]2)[cH:13][c:14](-[c:16]2[cH:17][cH:18][c:19]([C:22](=[O:23])[N:24]4[CH2:25][CH2:26][O:27][CH2:28][CH2:29]4)[cH:20][cH:21]2)[s:15]3)[cH:30][cH:31]1)[C:46]([c:42]1[c:41](=[O:49])[n:40]([CH2:33][c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[cH:45][cH:44][n:43]1)=[O:47]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-83f55e72d3a6485bac9ec5929d2817f2
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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