2-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline → 5-Chloro-4-(1H-indol-3-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine

Reaction equation

[CH3:18][O:19][c:20]1[c:21]([NH2:22])[cH:23][cH:24][c:25]([N:27]2[CH2:28][CH2:29][CH:30]([N:33]3[CH2:34][CH2:35][N:36]([CH3:39])[CH2:37][CH2:38]3)[CH2:31][CH2:32]2)[cH:26]1.[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:17])[c:6](-[c:8]2[cH:9][nH:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]23)[n:7]1>>[c:2]1([NH:22][c:21]2[c:20]([O:19][CH3:18])[cH:26][c:25]([N:27]3[CH2:28][CH2:29][CH:30]([N:33]4[CH2:34][CH2:35][N:36]([CH3:39])[CH2:37][CH2:38]4)[CH2:31][CH2:32]3)[cH:24][cH:23]2)[n:3][cH:4][c:5]([Cl:17])[c:6](-[c:8]2[cH:9][nH:10][c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]23)[n:7]1

Participants

Reactant 2

HCID 457899912-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline

HCID 566553763-(2,5-Dichloropyrimidin-4-yl)-1H-indole

Product 1

HCID 566553745-Chloro-4-(1H-indol-3-yl)-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)pyrimidin-2-amine

Sources & evidence

ORD record: ord-60f65e513ae3466f8cd6f6c8b46afa20
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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