4-[(1-Methyl-1H-pyrazol-3-yl)amino]quinazolin-6-ol → 6-({3-chloro-5-[2-(ethylamino)ethoxy]pyridin-2-yl}oxy)-N-(1-methyl-1H-pyrazol-3-yl)quinazoline-4-amine hydrochloride

HRID 81632

Reaction equation

HRID 81632 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][C:4]([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([OH:18])[CH:16]=3)[N:11]=[CH:10][N:9]=2)=[N:3]1.[Cl:19][C:20]1[C:25]([Cl:26])=[CH:24][C:23]([O:27][CH2:28][CH:29](OCC)OCC)=[CH:22][N:21]=1.[CH2:36]([NH2:38])[CH3:37].O1CCCC1>>[ClH:19].[Cl:26][C:25]1[C:20]([O:18][C:15]2[CH:16]=[C:17]3[C:12](=[CH:13][CH:14]=2)[N:11]=[CH:10][N:9]=[C:8]3[NH:7][C:4]2[CH:5]=[CH:6][N:2]([CH3:1])[N:3]=2)=[N:21][CH:22]=[C:23]([O:27][CH2:28][CH2:29][NH:38][CH2:36][CH3:37])[CH:24]=1

Participants

4

Reactant 3

HCID 231603824-[(1-Methyl-1H-pyrazol-3-yl)amino]quinazolin-6-olHCID 66726184Ethylamine tetrahydrofuranHCID 866458962,3-Dichloro-5-(2,2-diethoxyethoxy)pyridine

Product 1

HCID 426015156-({3-chloro-5-[2-(ethylamino)ethoxy]pyridin-2-yl}oxy)-N-(1-methyl-1H-pyrazol-3-yl)quinazoline-4-amine hydrochloride

Procedure

Using 4-[(1-methyl-1H-pyrazol-3-yl)amino]quinazolin-6-ol obtained in Example 1-1) and 2), and 2,3-dichloro-5-(2,2-diethoxyethoxy)pyridine and 2 M ethylamine/tetrahydrofuran solution, and in the same manner as in Example 1-3) and Example 10-2), or according to a method similar to it or according to a combination thereof with an ordinary method, the entitled compound (223 mg) was obtained as a pale yellow solid.

Sources & evidence

ORD record
ord-6d1b0ad4dc204ff7aac3b718c1d976c9
Source dataset
uspto-grants-2014_09
Patent number
US08846700B2

Linked notes

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