Dichloromethane → 2-(2,5-Dichloro-pyrimidin-4-ylamino)-3-fluoro-phenol

HRID 816395Notes

Reaction equation

[B:19]([Br:20])([Br:21])[Br:22].[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:18])[c:6]([NH:8][c:9]2[c:10]([F:17])[cH:11][cH:12][cH:13][c:14]2[O:15][CH3:16])[n:7]1.[Cl:23][CH2:24][Cl:25]>>[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:18])[c:6]([NH:8][c:9]2[c:10]([F:17])[cH:11][cH:12][cH:13][c:14]2[OH:15])[n:7]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 25134Boron tribromide

HCID 86633994(2,5-Dichloro-pyrimidin-4-yl)-(2-fluoro-6-methoxy-phenyl)-amine

Product 1

HCID 866339952-(2,5-Dichloro-pyrimidin-4-ylamino)-3-fluoro-phenol

Sources & evidence

ORD record: ord-e40093505ab6431cb77be208d380a40f
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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