Dimethylamine tetrahydrofuran → 6-({5-[2-(dimethylamino)ethoxy]pyridin-2-yl}oxy)-N-pyrazin-2-ylquinazoline-4-amine

HRID 81657

Reaction equation

HRID 81657 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([OH:18])[CH:16]=2)[N:11]=[CH:10][N:9]=1.C(O[CH:22](OCC)[CH2:23][O:24][C:25]1[CH:26]=[CH:27][C:28](F)=[N:29][CH:30]=1)C.[CH3:35][NH:36][CH3:37].O1CCCC1>>[CH3:35][N:36]([CH3:37])[CH2:22][CH2:23][O:24][C:25]1[CH:26]=[CH:27][C:28]([O:18][C:15]2[CH:16]=[C:17]3[C:12](=[CH:13][CH:14]=2)[N:11]=[CH:10][N:9]=[C:8]3[NH:7][C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)=[N:29][CH:30]=1

Participants

4

Reactant 3

HCID 22320367Dimethylamine tetrahydrofuranHCID 684297065-(2,2-Diethoxyethoxy)-2-fluoropyridineHCID 1363347444-(Pyrazin-2-ylamino)quinazolin-6-ol

Product 1

HCID 595088406-({5-[2-(dimethylamino)ethoxy]pyridin-2-yl}oxy)-N-pyrazin-2-ylquinazoline-4-amine

Procedure

Using 4-(pyrazin-2-ylamino)quinazolin-6-ol, 5-(2,2-diethoxyethoxy)-2-fluoropyridine and 2 M dimethylamine/tetrahydrofuran solution, and in the same manner as in Example 31 or according to a method similar to it or according to a combination thereof with an ordinary method, the entitled compound (13 mg) was obtained as a pale yellow amorphous solid.

Sources & evidence

ORD record
ord-3488a865315b4999b43bea5c38d6c3c2
Source dataset
uspto-grants-2014_09
Patent number
US08846700B2

Linked notes

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