Acrylic Acid → HCID 24989915, compound

HRID 81719

Reaction equation

HRID 81719 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([NH2:21])[CH:16]=2)[N:9]=1.[C:22](O)(=[O:25])[CH:23]=[CH2:24]>>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7][C:8]1[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C:15]2[CH:16]=[C:17]([NH:21][C:22](=[O:25])[CH:23]=[CH2:24])[CH:18]=[CH:19][CH:20]=2)[N:9]=1

Participants

3

Reactant 2

HCID 6581Acrylic AcidHCID 68749996N1-(4-(pyridin-2-ylthio)pyrimidin-2-yl)benzene-1,3-diamine

Product 1

HCID 24989915HCID 24989915, compoundYield 43%

Procedure

In a procedure analogous to Example 15, reaction of N1-(4-(pyridin-2-ylthio)pyrimidin-2-yl)benzene-1,3-diamine (35 mg, 0.12 mmol) and acrylic acid (16 μL, 0.24 mmol) furnished the product (18 mg, 43%).

Sources & evidence

ORD record
ord-7f4e5cc36887435cbbdc295e9f320425
Source dataset
uspto-grants-2014_09
Patent number
US08846704B2

Linked notes

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