Iodoacetonitrile → (6-Isopropyl-1,3-dimethyl-1H-indol-5-yloxy)-acetonitrile

HRID 81760

Reaction equation

[CH:1]([C:4]1[CH:12]=[C:11]2[C:7]([C:8]([CH3:14])=[CH:9][N:10]2[CH3:13])=[CH:6][C:5]=1[OH:15])([CH3:3])[CH3:2].I[CH2:17][C:18]#[N:19]>>[CH:1]([C:4]1[CH:12]=[C:11]2[C:7]([C:8]([CH3:14])=[CH:9][N:10]2[CH3:13])=[CH:6][C:5]=1[O:15][CH2:17][C:18]#[N:19])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 69356Iodoacetonitrile

HCID 595985476-isopropyl-1,3-dimethyl-1H-indol-5-ol

Product 1

HCID 59598566(6-Isopropyl-1,3-dimethyl-1H-indol-5-yloxy)-acetonitrile

Procedure

(6-Isopropyl-1,3-dimethyl-1H-indol-5-yloxy)-acetonitrile was prepared from 6-isopropyl-1,3-dimethyl-1H-indol-5-ol by treatment with iodoacetonitrile using the procedure of step 5 of Example 2 above.

Sources & evidence

ORD record: ord-95ee1b0990a94da1ae1ef360db668cb6
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08846705B2

Linked notes

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