Ammonium → 1,1-dimethylethyl 3-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-azetidinecarboxylate

Reaction equation

[Br:1][c:2]1[cH:3][n:4]([CH:12]2[CH2:13][N:14]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:15]2)[c:5]2[n:6][cH:7][n:8][c:9]([Cl:11])[c:10]12.[NH4+:23].[OH-:24]>>[Br:1][c:2]1[cH:3][n:4]([CH:12]2[CH2:13][N:14]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:15]2)[c:5]2[n:6][cH:7][n:8][c:9]([NH2:23])[c:10]12

Participants

Reactant 3

HCID 223Ammonium

HCID 961Hydroxide

HCID 866636801,1-dimethylethyl 3-(5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-azetidinecarboxylate

Product 1

HCID 668235231,1-dimethylethyl 3-(4-amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-1-azetidinecarboxylate

Sources & evidence

ORD record: ord-9b6cf688e76e447cb8a1f6317aafd983
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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