Bicarbonate Ion → 5-Bromo-3-[[1,3]dioxan-5-yl-(trans-4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid methyl ester

Reaction equation

[CH3:1][O:2][C:3](=[O:4])[c:5]1[s:6][c:7]([Br:25])[cH:8][c:9]1[N:10]([C:11](=[O:12])[CH:13]1[CH2:14][CH2:15][CH:16]([CH3:19])[CH2:17][CH2:18]1)[CH:20]([CH2:21][OH:22])[CH2:23][OH:24].[Na+:30].[O-:26][C:27]([OH:28])=[O:29].[O:31]1[CH2:32][CH2:33][O:34][CH2:35][CH2:36]1>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[s:6][c:7]([Br:25])[cH:8][c:9]1[N:10]([C:11](=[O:12])[CH:13]1[CH2:14][CH2:15][CH:16]([CH3:19])[CH2:17][CH2:18]1)[CH:20]1[CH2:21][O:22][CH2:27][O:24][CH2:23]1